Why CBD and caffeine?

Well, for one thing, CBD  enhances the caffeine but reduces the jitters. 

"CBD can further enhance the feeling of mental alertness produced by caffeine by interacting with some of the same neurotransmitters responsible for carrying out the effects.

Mental alertness is controlled by a few key neurotransmitters in the brain. One of the most important is adenosine.

As more adenosine builds up, our neurons become progressively slower at sending messages. This makes us feel slow and tired. It’s designed to help us wind down to fall asleep at night.

Caffeine blocks the effects of adenosine by attaching to the receptors itself — thereby preventing adenosine from doing its job — keeping us awake when we would otherwise feel tired.

CBD offers many of its own benefits through its interaction with adenosine, but the interaction is much more complex than it is with caffeine — it’s considered a modulator of adenosine. This means that CBD appears to work by improving the efficiency of the adenosine receptors directly].

Other effects of CBD may come through its interaction with serotonin — often considered the “happy” neurotransmitter.  Increased serotonin activity leads to a greater sense of well-being and motivation."

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Another starring cannabinoid in Zogena's new proprietary oils is CBDV.  Research suggests it is a powerhouse of health benefits, too. 

" so, this doesn’t exhaust the potential indications of CBDV’s neurological effects. The cannabinoid was tested in a mouse model of Rett syndrome, which is linked to behavioral and psychological symptoms in girls (e.g., speech and motor coordination difficulties and seizures). The study found CBDV beneficial on multiple levels, including motor coordination. [1]

To reinforce these results, CBDV appears to effect “complete rescue of recognition memory deficits” of male mice with the same genetic mutation that causes Rett syndrome, as well as to transiently delay neurological defects. [2]

On a somewhat related note, CBDV is also being explored as a potential remedy for some of the behavioral, social, and cognitive plights of autism specter disorder (ASD), which can increase the chances of epileptic episodes.

The body of promising research doesn’t end there. CBDV was also found to “prevent the loss of locomotor activity, reduce inflammation, and restore autophagy” in mice with Duchenne muscular dystrophy (DMD). [3]

And on a different note, CBDV inhibits nausea receptors in rodents, possibly through its interaction with transient receptor potential (TRP) channel receptors. [4]

As you can see, despite CBDV perhaps living in CBD’s large shadow for now, it certainly has the medicinal merit to make a name for itself, especially as it becomes the object of research involving humans".

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